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ONX-0801, 卵巢癌治療藥物有突破性研發

張碧瑜 / 癌症資訊網

ONX-0801偽裝成葉酸,進入癌細胞內,抑制胸苷酸合成酶,這是新型藥物的首次嘗試。此研究的負責人Udai Banerji(英國癌症研究所藥物發展部副部長兼倫敦皇家Marsden NHS基金會副會長)表示,“這是全新的作用機制。”
癌症協會的報告指出,在澳洲,僅44%的卵巢​癌患者在確診后能存活5年。卵巢​癌症狀包括: 腹脹;食欲不振或很快有飽腹感;尿頻或尿急;背部、腹部或骨盆疼痛;便秘;月經失調;疲憊;消化不良;性行為期間疼痛等。
Full coverage

Biggest ovarian cancer breakthrough in a decade hailed by researchers

The Independent - ‎Jun 2, 2017‎
Experts called results of the early-phase study “exciting” and “promising” after patients who had exhausted all other treatment options showed an impressive response. The drug, known as ONX-0801, was tested in 15 women with advanced ovarian cancer as ...

Experimental ovarian cancer treatment looks 'very promising', researchers say

The Guardian - ‎Jun 2, 2017‎
An experimental new treatment for ovarian cancer led to a dramatic shrinking of tumors in a small, early-phase study. Researchers were testing a drug, known as ONX-0801, for safety, but found that tumors in half of the 15 women studied shrank during ...

'Biggest breakthrough in 10 years' in treatment of ovarian cancer

Mirror.co.uk - ‎Jun 2, 2017‎
Scientists have made the biggest breakthrough in a decade in the treatment of advanced ovarian cancer . Seven out of 15 women taking new drug ONX-0801 in a trial run by London's Royal Marsden Hospital were told their tumours had shrunk dramatically.

ASCO 2017: Ovarian cancer drug delivers 'very promising' results in early trial

The Institute of Cancer Research - ‎Jun 2, 2017‎
A team at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust tested the drug, known in the study as ONX-0801, in 15 women with ovarian cancer as part of a wider phase I clinical trial. Phase I trials are run in ...

Ovarian cancer drug hailed as 'biggest breakthrough in a decade'

Sky News - ‎Jun 2, 2017‎
The trial was part of a larger study by the Institute of Cancer Research (ICR) and the Royal Marsden NHS Foundation Trust in London. ONX-0801 enters the cancer cells by mimicking folic acid - ovarian cancer has a large number of receptors for folic acid.

Researchers hail 'breakthrough' drug for treating ovarian cancer

The New Daily - ‎Jun 3, 2017‎
Researchers are hailing an experimental drug as a major advance in the treatment of ovarian cancer, which typically claims the lives of up to 1400 Australian women every year. The drug, known as ONX-0801, is being described as the biggest breakthrough ...

Drug shrinks ovarian tumours in early trial

BBC News - ‎Jun 2, 2017‎
NHS Choices: Ovarian cancer. The researchers, from the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust in London, wanted to establish whether the drug, known in the study as ONX-0801, was safe, so they tested it on a small ...

'Biggest breakthrough in a decade': New ovarian cancer drug proves hugely promising

RT - ‎Jun 3, 2017‎
The trial also found that because ONX-0801 targets cancer cells specifically, while leaving healthy cells alone, patients did not experience common side effects such as infections, diarrhoea, nerve damage and hair loss associated with traditional ...

Scientists make 'biggest breakthrough in ovarian cancer for 10 years'

Evening Standard - ‎Jun 3, 2017‎
Cancer patients who had run out of other options responded well to the new drug in a medical advance which experts have hailed as “exciting” and “promising”. The drug – called ONX-0801 – was tested on 15 woman with advanced ovarian cancer in the first ...

Cancer patient hails 'highly promising' new treatment after tumours shrink

ITV News - ‎Jun 3, 2017‎
A new treatment for ovarian cancer has been hailed "highly promising" by researchers after it was found to significantly shrink tumours. Seven out of 15 women with advanced ovarian cancer, who had exhausted all other treatment options, saw their ...

Groundbreaking new drugs give months of extra life for women suffering from ovarian cancer

Telegraph.co.uk - ‎Jun 2, 2017‎
Current efforts to combat the ovarian cancer mainly focus on targeted therapies which try to match interventions with certain gene types. But researchers say the new ONX-0801 drug has could be of benefit a wide cohort of women with advanced ovarian ...

This Could Be The Biggest Breakthrough In Treating Ovarian Cancer For A Decade

Refinery29 - ‎Jun 3, 2017‎
ONX-0801 works by mimicking folic acid to enter the cancer cells, and then killing them by halting the action of a protein called hymidylate synthase. Because it targets cancer cells specifically, it carries none of the side effects associated with ...

Ovarian cancer drug shrinks tumours in trials

The Times (subscription) - ‎Jun 2, 2017‎
Only one in three women with the cancer will survive for more than ten years and it causes 4,000 deaths a year in Britain. Scientists at the Institute of Cancer Research have developed a compound, ONX-0801, that sneaks into the tumour by disguising ...

New drug shrinks ovarian tumors in early trial

kwbe - ‎Jun 3, 2017‎
(CHICAGO) — A new treatment for ovarian cancer has shown “promising” results in women who are in the advanced stages of the disease, according to the BBC. The drug, known as ONX-0801, shrunk tumors in more than half the patients who participated in ...

Scientists develop new targeted ovarian cancer treatment with no side effects

AppsforPCdaily - ‎Jun 3, 2017‎
The team tested the drug, ONX-0801, in 15 women with ovarian cancer as part of a wider phase I clinical trial. The drug had significantly shrunk tumors in seven of the patients who carried the specific molecule that the drug was created to target. Her ...

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